Testosterone Cypionate is a synthetic version of testosterone, but it is going to offer the body the same benefits as natural produced testosterone. There are a variety of responsibilities this hormone offers for the male body on a mental and physical level. This includes: fat loss, lean muscle mass, increases bone density, reduces the risk of heart disease, sex drive
Testosterone Cypionate is both androgenic and anabolic, making it a great choice if you are looking to gain both strength and size. Those are common goals for athletes and part of why they are encouraged to us this testosterone. It also promotes the retention of nitrogen, and that helps the muscles to develop in less time
Testosterone cypionate is a synthetic derivative of testosterone in the form of an oil-soluble 17 (beta)-cyclopentylpropionate ester. Its benefit compared to other testosterone derivatives is the slow rate of release after injection and longer half-life.
Testosterone cypionate is used in males that present conditions derived from a deficiency or absence of endogenous testosterone. These conditions are 1) primary hypogonadism, defined as the testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome or orchidectomy; and 2) hypogonadotropic hypogonadism characterized by idiopathic gonadotropin, LHRH deficiency or pituitary-hypothalamic injury from tumors, trauma or radiation.
Administration of ester derivatives of testosterone as testosterone cypionate generates an increase in serum testosterone to levels reaching 400% from the baseline within 24 hours of administration.
These androgen levels remain elevated for 3-5 days after initial administration.3 The continuous variation in plasma testosterone after intramuscular administration of testosterone cypionate results in fluctuations in mood and libido as well as some local inflammation.
All testosterone, including Testosterone Cypionate, binds to the androgen receptor. This promoters both fat loss and encourages muscle building. As a result, the size and the shape of the muscle fibers can change. The androgens will help to protect the muscle you have created through your diet and workout routine. Testosterone Cypionate is also going to increase the amount of red blood cells to help with endurance. Recovering in less time from strenuous activity will help you to feel better.
It isn’t uncommon for athletes to see improvement in their overall strength with the use of Testosterone Cypionate. The hormone works to improve the contractions in the muscles and the neuromuscular transmissions. The synthesis of glycogen is improved and that gives the body fuel to get through those very intense workouts sessions. All of this adds up to more strength and endurance when Testosterone Cypionate is used by athletes.
The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5-alpha-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5-alpha-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T.
The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.
Testosterone cypionate, following conversion into testosterone, is approximately 98% protein-bound to sex hormone-binding globulin in plasma.
Metabolism: To start its activity, testosterone cypionate has to be processed by enzymes in the bloodstream. These enzymes will break the bond between the cypionate ester moiety and the testosterone. Once separated, testosterone is metabolized to 17-keto steroids through two different pathways. The major active metabolites are estradiol and dihydrotestosterone (DHT). Testosterone is metabolized to DHT by steroid 5α-reductase in skin, liver and urogenital tract. In reproductive tissues DHT is further metabolized to androstanediol.
Absorption: Testosterone cypionate is an esterified anabolic which allows it to present a greater degree of solubility in fats and thus, the release and absorption occur in a slow rate compare to homologous molecules.5 Intramuscular administration of 200 mg of testosterone cypionate produced a mean supratherapeutic Cmax of 1122 ng/dl which occurred 4-5 days post-injection. After the fifth day, the levels of testosterone cypionate in plasma went down reaching an average of 400 ng/dl.
Route of elimination: About 90% of a dose of testosterone given intramuscularly is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6% of a dose is excreted in the feces, mostly in the unconjugated form.
Half life: The half-life of testosterone cypionate is one of the longest, being approximately of 8 days.
All medicines may cause side effects, but many people have no, or minor, side effects. Some medical conditions may interact with Testosterone Cypionate.
Tell your doctor or pharmacist if you have any medical conditions.
The most common side effects: gynecomastia, high blood pressure, water retention, acne, enlarged prostate, hair loss
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.
